Interesting podcast over at Journal of Applied Physiology

A few weeks ago, I have posted an article alert regarding two papers published in J Appl Physiol challenging the assumption that the diameter of the middle cerebral artery remains constant in response to changes in hypo- and hypercapnia.

You can now listen to a podcast where Kevin Shoemaker (Senior author on Covervale et al. paper), Jasper Verbree (First author of the second paper) and Phil Ainslie (who published an editorial related to these two manuscripts) further discuss the results of these papers.  Really interesting !

I have also added a link to this podcast in the Cerebrovascular Physiology links section of the blog.


2 thoughts on “Interesting podcast over at Journal of Applied Physiology

  1. Coverdale et al. used phase-contrast MRI (instead of spin-echo MRI), so was able to generate vascular diameters with higher temporal resolution than did Verbree et al. Since it’s not clear at which part of the hypo- or hypercapnia challenge the vessel diameter was measured, a higher temporal resolution would be preferable. Maybe the vascular response changes with length of time it’s been in a certain steady state.

    Also, mean arterial pressure should be factored into the diameter calculations. In that respect, if 2 experimental protocols involved different PETCO2 changes, then they are not necessarily comparable anyway. See for example:
    Regan, R. E., Fisher, J. A., & Duffin, J. (2014). Factors affecting the determination of cerebrovascular reactivity. Brain and Behavior, 4(5), 775–788. doi:10.1002/brb3.275

    1. Thank you for your comments Jean. I agree that MAP should be taken into consideration (I have that paper in mind: Battisti-Charbonney et al. J Physiol 589.12 (2011) pp 3039–3048).

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