Cerebrovascular physiology – article alert #88

Cardiac surgery and the brain

443- A systematic review of cerebral oxygenation-monitoring devices in cardiac surgery – Douds et al.

Hypoxia and the brain

444- Cerebral blood flow response to acute hypoxic hypoxia – Harris et al.

Brain reactivity to carbon dioxide

445- Cerebrovascular Reactivity to Carbon Dioxide Under Anesthesia: A Qualitative Systematic Review – Mariappan et al.

446- Measuring cerebrovascular reactivity: what stimulus to use? Fierstra et al.

447- Assessment of Cerebrovascular Reactivity during Resting State Breathing and Its Correlation with Cognitive Function in Hypertension – Hajjar et al.

Cardiopulmonary bypass and the brain

448- The impact of haemodilution and bypass pump flow on cerebral oxygen desaturation during cardiopulmonary bypass – A comparison of two systems of cardiopulmonary bypass – Bennett et al.

Diabetes and the brain

449- Cerebral hemodynamics and systemic endothelial function are already impaired in well-controlled type 2 diabetic patients, with short-term disease – Palazzo et al.

Exercise and the brain

450- Cerebral volumetric changes induced by prolonged hypoxic exposure and whole-body exercise – Rupp et al.

Blood pressure and the brain

451- Fundamental relationships between blood pressure and cerebral blood flow in humans-  Tzeng et al.


Article alert – Special edition

Below are two important papers recently published challenging the assumption that the diameter of the middle cerebral artery remains constant in response to hypocapnia and hypercapnia (using MRI technology) as previously reported.

Cerebral blood flow velocity underestimates cerebral blood flow during modest hypercapnia and hypocapniaCoverdale et al.

Assessment of middle cerebral artery diameter during hypocapnia and hypercapnia in humans using ultra high-field MRIVerbree et al.

Overall, these results suggest that the middle cerebral artery vasodilates in response to hypercapnia and vasoconstricts in response to hypocapnia, and that changes in blood flow velocity monitored with transcranial Doppler methodology (which assumes a constant diameter of the middle cerebral artery) underestimate changes in cerebral blood flow with some important implications for the evaluation of cerebrovascular reactivity to carbon dioxide. These results also question the validity of transcranial Doppler ultrasound, at least during changes in carbon dioxide…

Because science is not that simple and the fact that these two studies do not agree on everything, I suggest you to read the invited editorial related to the two above-mentioned papers:

Transcranial Doppler ultrasound: Valid, Invalid, or Both ? Ainslie and Hoiland

Fascinating readings !

Maybe we could further discuss the results/methodology related to these papers over here ?

What do you think ?

Cerebrovascular physiology – article alert #87

Sepsis and the brain

436- Transcranial Doppler to assess sepsis-associated encephalopathy in critically ill patients – Pierrakos et al.

Cardiovascular disease and the brain

437- The Synergistic Effects of Anxiety and Cerebral Hypoperfusion on Cognitive Dysfunction in Older Adults With Cardiovascular Disease – Alosco et al.

Brain monitoring

438- Cerebral blood flow velocity underestimates cerebral blood flow during modest hypercapnia and hypocapnia – Coverdale et al.

Subarachnoid hemorrhage and the brain

439- Bilateral Failure of Cerebral Autoregulation is Related to Unfavorable Outcome After Subarachnoid Hemorrhage – Budohoski et al.

Preeclampsia and the brain

440- Cerebral Oximetry Assessed by Near-Infrared Spectrometry During Preeclampsia: An Observational Study: A Preliminary Study of the Impact of Magnesium Sulfate Administration – Guerci et al.

Vasopressors and the brain

441- Differing effects when using phenylephrine and norepinephrine to augment cerebral blood flow after traumatic brain injury in the immature brain – Friess et al.

Exercise and the brain

442- Evidence Cerebral Blood-Flow Regulation Mediates Exercise-Cognition Links in Healthy Young Adults – Guiney et al.

Our research topic is almost ready to become an e-book!

Somewhere in 2013, I had the opportunity to organize a Frontiers Research Topic of my choice, which became the topic entitled Cerebral oxygenation in health and disease states. Regular readers followed my updates regarding that research topic.

I am happy to announce that 18 papers (original research, opinion and review papers) will be included in our research topic. I have submitted an editorial to Frontiers this morning, that will present those 18 papers…and the whole thing will officially become an e-book (click here to see what a Frontier’s e-book looks like).

While eagerly waiting for the final product to be ready, interested readers can still read those papers directly on the topic’s website (open access). I will keep you posted as soon as the e-book is published !

News from our research topic on cerebral oxygenation #15

Another update regarding our research topic on cerebral oxygenation.

The last three papers (#16 to 18) of our research topic now available at Frontiers in Physiology !

Ventilatory strategy during liver transplantation: implications for near-infrared spectroscopy-determined frontal lobe oxygenation by Henrik Sørensen, Hilary Grocott, Mads Niemann, Allan Rasmussen, Jens Hillingsø, Hans Frederiksen and Niels Secher

Cerebral hemodynamics during graded Valsalva maneuvers by Blake Perry, James Cotter, Gaizka Mejuto, Toby Mündel and Sam Lucas

Preserved frontal lobe oxygenation following calcium chloride for treatment of anesthesia-induced hypotension by Carl-Christian Kitchen, Peter Nissen, Niels Secher and Henning Nielsen

Go have a look!

Hey! You don’t want to miss that intensive course: Cardiovascular Ultrasound in Health & Exercise Sciences

Are you a grad student, postdoc or researcher who would like to develop/improve vascular, cerebrovascular and/or cardiac ultrasound skills ?

Well, you cannot miss that intensive course during which you will gain knowledge and practical skills related to the use of ultrasound applications.

This summer school will be held from July 13th to 17th 2015 at the Centre for Heart, Lung and Vascular Health, University of British Columbia – Okanagan Campus.

Importantly, registration closes on May 1st 2015.

You want more information ??

Just click on that link:

Cardiovascular Ultrasound in Health & Exercise Sciences