I just read another interesting manuscript by Ogoh’s team entitled Regional redistribution of blood flow in the external and internal carotid arteries during acute hypotension.
In that study, the authors were interested in the changes in external carotid artery (ECA) blood flow following acute hypotension and whether the latter changes influence internal carotid artery (ICA) blood flow regulation. The authors observed clear regional differences in ICA and ECA blood flow in response to acute hypotension (using the thigh cuff method). Indeed, while ICA blood flow lowered in response to hypotension and then quickly recovered to baseline levels, ECA blood was also reduced but that reduction in blood flow was maintained during the entire recovery period.
According to the authors
This finding suggests that the selective redistribution of blood flow from the ECA to support the recovery of ICA blood flow may reflect a neuroprotective mechanism that serves to optimize intracranial blood flow and oxygenation during acute hypotension.
In this sense, the peripheral vasculature associated with the ECA may be an important and hitherto unrecognized site that contributions toward intracranial cerebral blood flow regulation.
This is really interesting.
However, the aim of this small post is rather to point out that with the publication of such results, coupled to those suggesting regional differences in cerebral blood flow distribution during exercise, cerebral autoregulation and cerebrovascular reactivity to CO2, will it still be possible to monitor blood flow/blood flow velocity in only one cerebral artery (the beloved MCA for example) in upcoming studies ??
In a recent review on cerebral autoregulation, we have suggested that
New technologies permit a more integrative evaluation of the cerebrovascular function in response to different challenges. Future studies need to consider regional differences in CBF regulation during blood pressure manipulation
Let me revise that last sentence…
Future studies will have to consider regional differences in CBF regulation…whatever thinkable experimental conditions.
Trying to publish a story focusing on only one cerebral artery will most likely become, in a near future, as hard as to publish a vasopressor story using near-infrared spectroscopy alone…
What do you think?