Cerebrovascular physiology – article alert #20

Brain monitoring

81- Role of transcranial Doppler in cerebral hyperperfusion syndrome – Pennekamp et al.

82- Transcranial Doppler sonography as a potential screening tool for preanaesthetic evaluation: a prospective observational study – Fudickar et al.

Brain oxygenation

83- Cerebral oxygenation is highly sensitive to blood pressure variability in sick preterm infants – Wong et al.

Beta-blockade and the brain

84- Treatment with a highly selective β1 antagonist causes dose-dependent impairment of cerebral perfusion after hemodilution in rats – Hu et al.

Methods: On averaging continuous raw data

We now have the luxury (compared to the good old days) of continuously monitoring data during a study protocol. For example, one can acquire continuous beat-to-beat measurements of middle cerebral blood flow velocity (MCA V) during 5, 30, 180 minutes or even more.

When you start a new study, you may want to analyze your raw data:

1) using the same method described in that interesting paper you just read or,

2) as it has always been done in your lab.

So, at the end of data collection, you sit in front of your raw data which now need to be averaged. What’s your game plan ?

If you compare two 10-minute conditions (baseline and drug infusion; under steady-state for the last 5 min), you get your data averaged over the last 5 seconds of steady-state? 15 seconds ? 60 seconds? 180 seconds ? Why? Also, is it protocol-depend? Why?

Cerebrovascular physiology – article alert #19

Syncope and the brain

74- Cerebral critical closing pressure and CO2 responses during the progression towards syncope – Zuj et al.

Hypergravity and the brain

75- The relationship between brain cortical activity and brain oxygenation in the prefrontal cortex during hypergravity exposure – Smith et al.

Brain blood flow variability

76- Interindividual relationships between blood pressure and cerebral blood flow variability in the presence of intact and blunted cerebrovascular control – Tzeng and MacRae

Brain monitoring

77- Transcranial Doppler ultrasound: technique and application – Purkayastha and Sorond

78- Cerebral oximetry to adjust cerebral and systemic circulation after cardiac arrest – Taccone et al.

Antihypertensive drugs and the brain

78- Antihypertensive therapy and cerebral hemodynamics in executive mild cognitive impairment: Results of a pilot randomized clinical trial – Hajjar et al.

COPD and the brain

80- Additive effects of non-invasive ventilation to hyperoxia on cerebral oxygenation in COPD patients with exercise-related O2 desaturation – Rodrigues et al.