Regular readers will remember my research interests. Thanks to good friends, it has now become essential for my research projects evaluating the influence of certain vasopressors on brain oxygenation to invasively measure the levels of oxygen in the brain (specifically in the blood coming from the internal jugular vein). Indeed, a recent paper from my Danish colleagues suggested that changes in brain oxygenation (measured non-invasively by near-infrared spectroscopy), following manipulation of blood pressure by norepinephrine, could be partly influenced by changes in skin perfusion. I had the opportunity to measure jugular venous oxygen saturation in healthy volunteers and patients during my postdoc (in Copenhagen with that same group) and this is definitely a “must” for the kind of research project I am working on.
In front of this evidence, I decided to make an amendment to my current vasopressor study in order to add jugular venous oxygen saturation to existing measures. But remember, I am not in Copenhagen anymore…I didn’t know if it would be difficult for this amendment to be accepted.
I thus have presented my amendment to our Scientific committee first and soon received a positive answer. It was pretty scientifically obvious that we needed that measure. Then, we have (for that specific meeting, I have asked the anesthesiologist who will insert these lines to be present) tried to convince the Ethics committee…
Well, I am happy to inform you that blood samples from the internal jugular vein will be taken in that vasopressor study! Yay! As I have already mentioned, I am aware of only one lab in Canada that can insert catheters into the internal jugular vein in human volunteers. For the moment, I will be mostly interested in jugular venous oxygen saturation. However, I will now have the possibility of studying cerebral metabolism.
For those wondering what a catheter into the internal jugular vein looks like, well here it is (the catheter is advanced until the black arrow):
I am looking forward to seeing the results !!!